Correction: Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity
نویسندگان
چکیده
Author details Department of Cell Death and Proliferation, Institute of Biomedical Research of Barcelona (IIBB-CSIC, IDIBAPS), C/ Roselló 161 6°, Barcelona 08036, Spain. Department of Hemotherapy and Hemostasis, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, C/ Villarroel 170, Barcelona 08036, Spain. Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clinic, C/ Villarroel 170, Barcelona 08036, Spain. Translational Research Laboratory, Institut Català d'Oncologia (IDIBELL-ICO), Gran Via, km 2.7 s/n, L'Hospitalet de Llobregat 08907, Spain.
منابع مشابه
Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity
INTRODUCTION Growth arrest-specific gene 6 protein (GAS6) and protein S (ProS) are vitamin K-dependent proteins present in plasma with important regulatory functions in systems of response and repair to damage. They interact with receptor tyrosine kinases of the Tyro3, Axl and MerTK receptor tyrosine kinase (TAM) family, involved in apoptotic cell clearance (efferocytosis) and regulation of the...
متن کاملTAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus
INTRODUCTION The TAM (tyro 3, axl, mer) kinases are key regulators of innate immunity and are important in the phagocytosis of apoptotic cells. Gas6 and protein S are ligands for these TAM kinases and bind to phosphatidyl serine residues exposed during apoptosis. In animal models, absence of TAM kinases is associated with lupus-like disease. To test whether human systemic lupus erythematosus (S...
متن کاملGas6/TAM System: A Promising Target in Neuroimmunology
Growth Arrest Specific 6 (Gas6) is a vitamin K-dependent protein [1], the biological activity of which is mediated by TAM receptors, a family of Tyrosine Kinases which includes three different members: Tyro3, Axl and Mer [2]. TAM receptors are also activated by Protein S [3], which shares structural similarities with Gas6, but is mainly expressed in the liver and exerts an anticoagulant effect ...
متن کاملCodon 72 Polymorphism of p53 Gene and Hematologic Manifestations in Patients with Systemic Lupus Erythematosus
Background: Systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. The importance of some genes in the development of systemic lupus erythematosus has been implicated. The gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has ...
متن کاملPlasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus
OBJECTIVES SLE is a systemic autoimmune disease with an annual incidence of 3.8 per 100,000. Several pathogenic mechanisms are believed to be operating in SLE, including an impaired clearance of apoptotic cells, activation of the type I IFN pathway and generation of autoimmune leucocytes. Growth arrest-specific protein 6 (Gas6) and its receptor Axl are known to regulate inflammation and may be ...
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